The fourth round clash comes in the middle of United’s Carabao Cup semi-final against Nottingham Forest, but a 3-0 win at the City Ground means Ten Hag could opt for a rotation rather than against Reading in the upcoming second leg.
Jadon Sancho competes for his first United appearance since October, after his manager gave a positive update on Friday.
“I said he is on his way back, he is making strides, he is back in team training and we have to see when he is ready to go back into the games,” Ten Hag told reporters.
Harry Maguire could get a rare start when he returns from suspension, while Jack Butland will hope to make his debut in goal if Ten Hag opts to rest David de Gea.
Diogo Dalot is permanently out with injury, so Aaron Wan-Bissaka will continue at right-back, while Luke Shaw is doubtful and unlikely to be at risk. Tyrell Malacia is expected to keep his place.
Both Christian Eriksen and Casemiro may be rested but Marcus Rashford, looking to score at Old Trafford for the tenth game in a row, was able to start. He was sent off before the hour mark against Forest, suggesting there is a good chance he will be involved against Reading from the start.
There should be a place in the squad for Alejandro Garnacho, with the likes of Facundo Pellistri and Anthony Elanga hoping to make an appearance at some point.
Predicted Man United XI (4-2-3-1): Butland; Wan-Bissaka, Lindelof, Maguire, Malacia; McTominay, Fred; Garnacho, Fernandes, Rashford; Weghorst