Festival-goers can go there for information and support on drug use and can hand in their drugs for backstage checks, which can help detect high-risk drugs.
This year's drug harm reduction services at Electric Picnic are part of the HSE Safer Nightlife Harm Reduction Programme.
Two tents provide on-site support by more than 50 HSE-trained volunteers, dressed in purple and pink vests.
Two additional collection bins will be placed at medical areas, where people can deposit medicines for analysis.
An on-site drug testing laboratory provides real-time results that can be used in harm reduction interventions.
The HSE drugs.ie tents can be found in the Main Arena and at the Jimi Hendrix Campsite on Friday, Saturday and Sunday from 11am to 9pm.
Health Minister Colm Burke is encouraging “anyone considering taking drugs at Electric Picnic and other festivals to get involved with the HSE Safer Nightlife programme and volunteers”.
“While it is always safer not to use drugs, from a public health perspective it is important that we reduce the risks for those who choose to do so,” he said.
“We know that ongoing changes in the drug market bring additional risks.
“I firmly believe that we must address drug use as a public health issue and I fully support this targeted harm reduction initiative, now in its third year,” he added.
Nicki Kileen, HSE Emerging Drug Trends Project Manager, said the current drug market is “more dangerous than ever before”.
“MDMA pills, powders and crystals are more potent, making it easier to take too much without knowing it, which can lead to drug emergencies,” she said.
Ms Kileen warns that the number of deaths from MDMA could increase this year.
“We are aware that MDMA now ranges between 140mg – 240mg MDMA. In general, MDMA above 125mg is considered to have a higher risk of causing an MDMA emergency.
“This means that taking one pill or small amounts of powder can be extremely risky.
“Another worrying trend is the addition of powders to drinks. We expect this to become increasingly common.
“Ketamine use has increased dramatically and many people are unaware of its short- and long-term effects,” she said.
Ms Kileen added that the HSE tents at Electric Picnic are “safe places to drop off drugs” and are not monitored by An Garda Síochána.
“The more samples you submit, the better we can understand the national market. Your contribution will not only contribute to your safety, but also to the safety of others,” she added.
The HSE said the risks of drug use increase based on individual factors, such as physical and mental health.
They also said there could be several symptoms of the emergency, including headache, pain in arms and legs or overheating.
Speaking at Electric Picnic, Prof Eamon Keenan, National Clinical Lead in Addiction Services at HSE, said: “Following the very recent changes in the drug market, drug monitoring has become an important tool for reducing harm to drug users.”
“We recently saw the value of this approach after powerful synthetic opioids came onto the market. Through internal analytics, we were able to detect and respond quickly to an emerging drug threat.
“In the same way, this service can help us detect hazardous substances at events,” he added.