Zinchenko trained with his new team-mates on Friday after coming from Manchester City on a £32m deal and will immediately be given a run-out in red and white.
However, Fabio Vieira has yet to get his first minutes in a Gunners shirt after suffering a minor foot injury shortly after his arrival from Porto.
The 22-year-old has participated in the training but is not endangered in Orlando.
CLICK HERE TO FOLLOW ARSENAL VS CHELSEA LIVE!
Three other players not involved tonight are Emile Smith Rowe, Takehiro Tomiyasu and Kieran Tierney, all of whom were absent from training.
But manager Mikel Arteta still calls a strong starting line-up as the new Premier League season kicks off in less than two weeks, so players like Bukayo Saka, Martin Odegaard, William Saliba, Ben White, Gabriel Magalhaes and Thomas Partey are all coming in. the first XI.
Arsenal XI: Ramsdale; White, Saliba, Gabriel, Zinchenko; Partey, Xhaka; Saka, Odegaard, Martinelli; Jesus
Subscribers: Turner, Bellerin, Walters, Cedric, Tavares, Mari, Holding, Maitland-Niles, Lokonga, Elneny, Marquinhos, Pepe, Nelson, Balogun, Nketiah