Saliba is out Saturday Premier League match at the Emirates Stadium due to a back injury sustained in the Europa League earlier this month.
Holding, who has only started one top-flight match this season, against Crystal Palace before the international break, is expected to continue this weekend in the Frenchman’s absence.
“Rob already has a huge amount of experience at the club, in the Premier League, and I think he proved that in the right way in the last game against Palace,” Arteta said on Friday.
Thomas Partey is expected to be fit for Arsenal after missing Ghana’s draw with Angola on Monday. Striker Gabriel Jesus is also committed to starting after working on the training pitch during the international break.
“He’s very close to that (100 percent). In the last 10 days, he’s really taken a big step forward,” Arteta said of Jesus.
“You can see he’s loosened up, he doesn’t think about it. You can see that during training he creates all that chaos that he can create at unique moments. He is now in a very good place.”
However, Eddie Nketiah is still out for Arsenal, along with long-term absentees Takehiro Tomiyasu and Mohamed Elneny.
Arsenal predicted XI (4-3-3): Ramsdale; White, Company, Gabriel, Zinchenko; Odegaard, Partey, Xhaka; Saka, Jesus, Martinelli.
Saturday 3pm BST
Location: Emirates Stadium
Referee: Darren England
Arsenal squad of: Hein, Ramsdale, Turner; Gabriel, Holding, Kiwior, Tierney, White, Zinchenko; Odegaard, Partey, Foot, Smith Rowe, Trossard, Coquille, Xhaka; Jesus, Martinelli, Nelson.
Injured: Elneny (knee), Nketiah (ankle), Saliba (back), Tomiyasu (knee)