Phillips has been plagued by injuries since his £42 million transfer from Leeds United to City last summer.
But Gareth Southgate is ready to trust him in Naples in a midfield three with Jude Bellingham and Declan Rice.
Southgate are expected to go with a front three of Bukayo Saka, Harry Kane and Jack Grealish, with Grealish getting the nod over his City teammate Phil Foden.
Marcus Rashford and Mason Mount both miss the European Championship 2024 qualifier through injury along with Nick Pope and Raheem Sterling.
In defense, Kyle Walker and Reece James battle for right back, while Harry Maguire is likely to be trusted back in centre.
Ben Chilwell will try to oust Luke Shaw on the left.
Predict England XI: Pickford; Walker, Stones, Maguire, Shaw; Phillips, Rice, Bellingham; Saka, Kane, Grealish.