The Rams go to Anfield as huge underdogs, but the hosts are in the midst of a hugely busy run of games and are coming into the game after being pushed to their limits by Tottenham.
A number of long-term injured absentees will remain unavailable for Liverpool, including Luis Diaz (knee), Joel Matip (calf), Arthur Melo (thigh) and Diogo Jota (calf).
James Milner (concussion) could be fit while Naby Keita is approaching a return of a thigh problem.
Klopp is expected to call on a number of reserve players and young players for the third round.
Caoimhin Kelleher should start in goal and there could be a full debut for young Calvin Ramsay at right-back.
Curtis Jones, Alex Oxlade-Chamberlain, Kostas Tsimikas and Fabio Carvalho can all hope they have sat on the bench at Spurs.
Other young players who may be in the mix include Stefan Bajcetic, the 18-year-old defensive midfielder who has already made four appearances this season, plus Liverpool U23s top scorer Layton Hewitt and winger Kaide Gordon.
Assistant coach Pep Ljinders has media duties and will provide an update in the press conference on Tuesday.
Predicted Liverpool XI: Kelleher; Ramsay, Gomez, Van Dijk, Tsimikas; Oxlade-Chamberlain, Bajcetic, Jones; Elliott, Nunez, Carvalho.