The English defender was withdrawn during halftime Sunday 6-3 Manchester derby thrashing of United at the Etihad with a muscle problem and was not involved in training, meaning he is sidelined for the Danish opposition’s visit to Europe.
Midfielder Rodri returns to the bench against Copenhagen, but Walker’s Three Lions teammates John Stones and Kalvin Phillips are both still out.
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“We will train this afternoon and we will know exactly,” Pep Guardiola said of the latest City team news during his pre-match press conference on Tuesday.
“Rodri is feeling better, but I think Kyle is out. But we have training later.”
Asked if Phillips could be available for the World Cup, Guardiola added: “I hope so. I hope for him and the national team. But I’m not a physio – the doctor told me he’s fine.”
Ruben Dias was only fit enough for the bench against United, but will start here alongside Aymeric Laporte after playing his first few minutes of the season following knee surgery over the summer.
Given City’s strong position in Group G, rotation could be in order, especially with a trip to Liverpool in the Premier League on the way.
Guardiola has already confirmed Erling Haaland will need to rest now and then, but resisted it tonight.
Man City start XI vs FC Copenhagen (4-3-3): Ederson; Cancelo, Dias, Laporte, Gomez; Gundogan, Grealish, Silva; Mahrez, Alvarez, Haaland