Pep Guardiola may decide to introduce a handful of young players to his starting line-up for the match, but the decision as a fullback has been made for him after Cancelo’s red card against Fulham.
A one-game suspension is imposed halfway through the week, freeing up a spot for Sergio Gomez in the XI.
Injury-wise, Chelsea’s visit is expected to come too early for Kyle Walker (groin) and Kalvin Phillips (shoulder).
Rico Lewis could replace Walker as a right-back after a goal against Sevilla in the Champions League.
Cole Palmer and Josh Wilson-Esbrand, who both played in the third round of last season’s Carabao Cup, are also in the mix for a starting spot. Academy top scorers Carlos Borges and Adedire Mebude are well placed to make the bench.
Guardiola, who will face the media on Tuesday to provide a team news update, is unlikely to make too many changes, but Stefan Ortega should start in goal.
Erling Haaland could be reinstated in the lineup after scoring the late winner over the weekend following an ankle injury.
Predicted Manchester City XI: Ortega; Lewis, Dias, Laporte, Gomez; Palmer, Rodri, De Bruyne; Mahrez, Haaland, Foden.