A win would send the Black Stars through to the knockout stage and take at least some revenge for the controversial World Cup quarter-final between the two countries in 2010.
Luis Suarezonce the pantomime villain, made quite an impact in that game and while Ghana has completely changed since then, it’s not hard to imagine this young team wanting to right some wrongs.
Andre Ayew will almost certainly lead alongside Inaki Williams for Ghana, while Mohammed Kudus emerges as one of the players of the tournament.
Left back Gideon Mensah should be fit after replacing Baba Raham in the 3-2 win over South Korea earlier this week.
Meanwhile, Suarez could be recalled against a country that one of its reporters referred to him as the “devil” during a press conference on Thursday.
While ineffective against Korea, neither Edinson Cavani nor Darwin Nunez impressed against Portugal and the Uruguayans need their talisman to lift the mood after some underwhelming performances to date.
Barcelona defender Ronald Araujo is likely to be sidelined in another key blow to La Celeste and manager Diego Alonso.
Ghana predicted XI: Boom-Zigi; Lamptey, Amartey, Salisu, Mensah; Party, Abdul Samed; Kudus, A. Ayew, J. Ayew; Willems
Uruguay predicted XI: Rochet; Giminez, Coates, Goddess; Varela, De Arrascaeta, Valverde, Bentanur, Nunez; Suarez, Cavani