The top two matches between the teams later this season will play a big part in deciding whether to have blue or red ribbons on the League trophy in May, but for now the focus is on a blockbuster cup tie.
It has been three consecutive semi-finals for Jose Guardiola‘s side since they won the FA Cup in 2019, with surprisingly a league the City boss only has once.
That’s the same number of times as Arteta, who led his Arsenal side past City and then Chelsea in the final to come out on top at Wembley in 2020.
While both managers insist this match will have no impact on the title race, it could prove to be an important psychological boost for anyone advancing to the next round.
Where can you watch Manchester City vs Arsenal?
TV channel: In the UK, the game will be broadcast live and free on ITV, with broadcasts from 7.30pm GMT ahead of the 8pm kick-off.
Live stream: You can also watch the proceedings live online via the ITVX app and the ITV website.
Live blog: You can follow all the action on match day via Standard Sport’s live blog, with expert analysis from Simon Collings at the Etihad.